Are SARMs Liver Toxic?

We use affiliate links. If you purchase something using one of these links, we may receive compensation or commission.

are sarms liver toxicAre you wondering if SARMs are liver toxic? SARMs are very powerful drugs used to increase muscle mass and lose weight, but are SARMs liver toxic? We’ll take a look at these compounds to determine if they can damage your liver.

What are SARMs?

Selective androgen receptor modulators, also known as SARMs, are drugs that selectively target androgen receptors of skeletal muscle to increase muscle growth. These drugs were designed to treat conditions like osteoporosis and muscle wasting disease. Due to the way that SARMs effect muscle growth they have become very popular among bodybuilders and athletes.

SARMs are used by both men and women to help achieve their ideal physique and increase performance levels. SARMs have been used for weight loss and muscle building.

SARMs do have some side effects. Some of these include hormone shutdown, visual disturbances including blurred vision and yellow tint to vision, hair loss, gynecomastia, and possibly erectile dysfunction.

The legality of SARMs often comes up. Currently, it appears that SARMs are legal to buy and possess in many countries for medical research purposes. Due to this legal loophole, many athletes can acquire research-grade SARMs. However, it is probably illegal to consume these drugs outside of a clinical setting. You can find SARMs for sale in many places online. Use caution if you decide to purchase these chemicals for your research.

Learn more about SARMS in our article: What are SARMs?

Are SARMs Liver Toxic?

One of the main concerns of many oral drugs, including oral steroids, prohormones, and SARMs is the potential for these drugs to be liver toxic. This is due to the way that these drugs pass through the liver and are processed before being sent into the bloodstream. The liver is put under additional stress by these drugs and it can cause liver damage.

According to the United States Food and Drug Administration (FDA), SARMs show concerning the potential to damage the liver. They state: “Life-threatening reactions, including liver toxicity, have occurred in people taking products containing SARMs”. The FDA also goes on to state that SARMs may cause an increased risk of heart attack or stroke.

The biggest issue with SARMs is the lack of human trials. Most of the studies that have been done are performed on animals. Most of the evidence that we have is self-reported anecdotal evidence from bodybuilders and athletes that are experimenting with themselves. Thousands of people have used these compounds safely but the long-term effects, including liver toxicity and damage, are really an unknown.

There have been some publications that mention cases of apparent drug-induced liver damage associated with SARM use. In one case a previously healthy 24‐year‐old man presented with a 5‐week history of jaundice, anorexia, nausea, lethargy, and weight loss of 11bs. He used Ligandrol LGD-4033 for a 9-week cycle and had a history of binge drinking. The study doesn’t mention what dosage this user took. However, it does show severely elevated ALT and AST which are markers doctors used to determine liver health.

In another case a 49-year-old man presented with jaundice and severe itching. This person was said to have used RAD-140 for a 4 weeks cycle. Again dosage is not mentioned. He showed elevated liver enzymes shortly after the cycle. In this case, the study does mention that all of his liver tests went back into the normal range 12 months after the elevated liver enzyme test.


If you decide to try an oral SARM then you will want to watch for elevated liver enzymes and probably take a liver support supplement while you are on cycle and for a duration post cycle. However, even supplementing for liver support may not be enough to protect against liver damage.

In one case the damage to the liver appears to have been reversed by stopping the drugs. In the other case, a followup blood work was not performed.

If you decide to use SARMs you should be aware of the side effects, including the potential for liver damage. You must accept these risks if you decide to use these powerful drugs.

SARM Alternatives

If you’re afraid of the side effects of SARMs but are looking to build muscle faster, the good news is that there are some legal supplements available that can help. Testosterone boosting supplements can help you gain muscle and lose fat without the side effects associated with SARM usage. These supplements will not produce as pronounced effects as SARMs or steroids but they come with a greatly reduced risk of side effects.

Prices and images pulled from the Amazon Product Advertising API on: